Endocrine Abstracts

Hypothyroidism refers to a thyroid hormone (TH) deficiency which mainly affects women (10/1 ratio). The higher default incidence in women remains unexplained. Diagnosis of hypothyroidism is based on a single thyroid-stimulating-hormone (TSH) measurement albeit TSH secretion displays pulsatile patterns which are under the positive control of hypothalamic thyrotropin-releasing-hormone (TRH) and negative feedback exerted by THs. Pituitary thyrotrophs form the smallest (2-4%) pitu...

Introduction: The diagnosis of non-HIV lipodystrophies is challenging, especially since borderline forms with type 2 diabetes have been described (Strickland Diabetes Care 2013).Objective: To identify the most specific anthropometric and biological parameters enabling to differentiate lipodystrophic from obese and control subjects.Methods: This prospective study (clin.gov 2009-AO-1169-48) included 94 patients divided in 3 groups ad...

Aggressive adreno-cortical carcinoma (ACC) is a rare, aggressive malignancy, with poorly understood molecular pathogenesis. As a result, therapeutic options are currently limited, surgery being currently the lone curative modality. Most cases of ACC are sporadic, although some familial cancer syndromes (Li–Fraumeni, Beckwith–Wiedemann, MEN1, Carney complex, congenital adrenal hyperplasia, etc.) are associated with an increased incidence of ACC. The genes involved in ...